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., 1997). It was verified this effect was mediated throughout the CB1 receptor and happened at a dose which was not associated with clear side effects. This examine also shown a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a alone, major the authors to infer the existence of the endogenous tone of cannabinoid analgesia in neuropathy. However, the evidence for these lionwin55 kinds of tone through inflammation is controversial (Beaulieu et al
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